Uptake By Kidney Epithelial Cells. Gpx3 is synthesized by epithelial cells of the kidney proximal tubule 8 9 and secreted into the extracellular space from where it enters the blood. We hypothesized that mn uptake by alveolar epithelial cells is primarily mediated by zip8.
However the renal uptake mechanism for protamine is not clear. Functional uptake and efflux transporters including oat1 oat3 oct2 mdr1 mrp2 mrp4 mate1 and mate2k. Glomerulus filtration and renal tubule reabsorption.
Mirroring the in vivo situation a549 cells expressed higher levels of zip8 than cell models for the liver intestines and kidney.
Human renal proximal tubule epithelial cells rptec as an essential advanced model to express kidney drug transporters and toxicity the benefits of using sa7k an rptec clone. The uptake was na dependent saturable with respect to phosphate and na and energy dependent. We hypothesized that mn uptake by alveolar epithelial cells is primarily mediated by zip8. To test our hypothesis we used a549 cells a type ii alveolar cell line.