Parietal Epithelial Cells Kidney Function. Parietal epithelial cells comprise a heterogeneous cell population lining bowman s capsule. To test the hypothesis that pecs form an impermeable barrier to filtered protein through the formation of tight junctions tj studies were performed in normal animals and in the anti glomerular basement membrane gbm model of crescentic nephritis.
The renal corpuscle is made of parietal cells podocytes and mesangial cells. In this review we examine current knowledge about the role of pecs and their interactions with podocytes in development and under physiological conditions. Parietal epithelial cells represent a reservoir of renal progenitors in adult human kidney which generate novel podocytes during childhood and adolescence and can regenerate injured podocytes.
Pec share the same developmental lineage as podocytes and function as progenitors for nonproliferative podocytes.
These cells contain use the 2na glucose transporter discussed above for intestinal epithelial cells and thus can continue the transport of glucose up a very steep concentration gradient. The various tubules are made of columnar and cuboidal epithelial cells. Structures in the kidney include the renal corpuscle comprised of a glomerulus and bowman s capsule which filters the blood and various tubules through which blood and urine pass. The renal corpuscle is made of parietal cells podocytes and mesangial cells.