Kidney Renal Tubular Epithelial Cells. In this review we shift this concept to renal tubules as a driving force in the progression of kidney disease. Two mammalian cell lines are commonly used as models of the proximal tubule.
Renal proximal tubular epithelial cells ptepic play a crucial role in renal function. In response to injury tubular epithelial cells tecs can synthesize and secrete varieties of bioactive molecules that drive interstitial inflammation and fibrosis. They are the type most often found in.
The steady state proliferation of tubular cells has been.
Normally the tubular epithelium is mitotically quiescent. The scattered tubular cell stc phenotype was discovered as a uniform reaction of tubule cells triggered by injury. In this context several studies have begun to examine the functional role of tubular epithelial cells in this autoimmune disorder. In fibrosis tubular epithelial cells tecs are lost due to cell death and the remaining cells dedifferentiate leading to reduced expression of characteristic epithelial markers and increased expression of mesenchymal markers.