Kidney Histology Glomerular Basement Membrane. Endothelium of the glomerular capillaries glomerular basement membrane gbm and podocytes visceral layer of renal capsule. The glomerular basement membrane of the kidney is the basal lamina layer of the glomerulus the glomerular endothelial cells the glomeular basement membrane and the filtration slits between the podocytes perform the filtration function of the glomerulus separating the blood in the capillaries from the filtrate that forms in bowman s capsule.
It is a fused basement membrane of the endothelial cells and podocytes and also offers some support to the glomerular capillaries. Several kidney diseases that result in glomerulonephritis and consequent leakage of protein into the urine are caused by defects in basement membrane proteins. In both laminae rarae many molecules and proteins contribute to the negative charge of the basement membrane.
Histology kidney glomerulus by m komorniczak talk.
The incidence in the united states is about one per million per year. The glomerular basement membrane is a fusion of. Anti gbm antibody mediated glomerulonephritis usually presents with rapidly progressive glomerulonephritis. These dense deposits usually involve long segments of basement membrane but occasionally only a few loops are involved sausage string pattern.