Kidney Glomerular Basement Membrane. Severe structural abnormalities of the gbm result in enhanced albumin leakage. Thin basement membrane disease tbmd is an inherited disorder that mainly affects the glomeruli which are tiny tufts of capillaries small blood vessels in the kidneys that filter wastes from the blood.
Inflammatory glomerulonephritis most commonly does this but genetic abnormalities of gbm components are another important mechanism alport s syndrome. The glomerulus has a glomerular basement membrane consisting mainly of laminins type iv collagen agrin and nidogen which are synthesized and secreted by both endothelial cells and podocytes. Severe structural abnormalities of the gbm result in enhanced albumin leakage.
Severe structural abnormalities of the gbm result in enhanced albumin leakage.
Most affected individuals have in addition to the hematuria minimal proteinuria normal renal function a uniformly thinned glomerular basement membrane gbm and a family history of hematuria. The glomerular basement membrane is a fusion of. Anti glomerular basement membrane disease anti gbm disease is a disease that occurs as a result of injury to small blood vessels capillaries in the kidneys and or lungs. Most affected individuals have in addition to the hematuria minimal proteinuria normal renal function a uniformly thinned glomerular basement membrane gbm and a family history of hematuria.