Kidney Focal Segmental Glomerulosclerosis Histology. The focal and segmental glomerulosclerosis is a relatively frequent lesion produced by multiple causes. Focal only some of the glomeruli are involved as opposed to diffuse segmental only part of each glomerulus is involved as opposed to global glomerulosclerosis refers to scarring of the glomerulus a part of the nephron the functional unit of the kidney.
Therefore it is normally only diagnosed after a kidney biopsy of the kidney. Chronic kidney disease that has evolved into a major burden for society 1 chronic kidney disease is one of the most signif icant risk factors for cardiovascular complications. Focal and segmental glomerulosclerosis fsgs is the most common histological finding.
When these filters are damaged they become scarred.
Fsgs presents similarly to minimal change disease but is not usually responsive to steroid therapy and has progressive glomerular filtration rate loss. Fsgs is scarring within the kidney that can only be seen clearly under the microscope. Focal and segmental glomerulosclerosis fsgs is the most common histological finding. So far most studies investigating the pathogenesis of fsgs.