Kidney Epithelial Cells Receptor. Kidney injury molecule 1 is a phosphatidylserine receptor that confers a phagocytic phenotype on epithelial cells takaharu ichimura edwin j p v. Its activation results in beneficial or detrimental consequences depending on the particular setting.
Human and mouse lung and kidney epithelial cells express kim 1 and endocytose nanoparticles displaying the sars cov 2 spike protein virosomes. We report that kidney injury molecule 1 t cell immunoglobulin mucin domain 1 kim 1 tim 1 is expressed in lung and kidney epithelial cells in covid 19 patients and is a receptor for sars cov 2. Interestingly in all concentrations of tnf α exposure the p erk1 2 level was significantly elevated in hypoxia compared to that of normoxic group.
Caveolin 1 is the principal component of caveolae the knockdown of caveolin 1 by rna interference rnai decreased the number of membrane caveolae to test whether the entry of jev into pk15 cells occurs via caveolae.
In short tnf α treatment reduced cell viability and the phosphorylation of erk1 2 and p38 in rat kidney epithelial cells but increased the expression of t erk1 2 and t p38 protein levels. Finally disrupting tnf α production specifically within the renal tubular epithelium attenuated the aki and the increase in circulating tnf α levels induced by cisplatin. Kidney injury molecule 1 is a phosphatidylserine receptor that confers a phagocytic phenotype on epithelial cells takaharu ichimura edwin j p v. Host expression indicates the tissue expressing the receptor in host data mostly recovered in human protein atlas.