Kidney Epithelial Cells Endocytosis. Receptor mediated endocytosis is a pivotal function of renal proximal tubule epithelial cells ptecs to reabsorb and metabolize substantial amounts of proteins and other substances in glomerular filtrates. This endocytotic block may involve a reduced capacity of phosphorylated aqp2 to interact with components of the endocytotic machinery.
Endocytosis of com crystals was inhibited by diverse molecules including tamm horsfall glycoprotein thp the tetrapeptide arginine glycine aspartic acid serine. The function accounts for the conservation of nutrients including carrier bound vitamins and trace elements filtered by glomeruli. The most common crystal in kidney stones calcium oxalate monohydrate com when added to cultures of monkey kidney epithelial cells bsc 1 line was internalized by 19 of the cells after 30 min.
Com crystal endocytosis was enhanced by serum adp and epidermal growth factor which are potent mitogens for these cells.
The epithelial cells lining the proximal tubules of the kidney reabsorb a large amount of filtered ions and solutes owing to receptor mediated endocytosis and polarized transport systems that reflect final cell differentiation. Endocytosis of com crystals was inhibited by diverse molecules including tamm horsfall glycoprotein thp the tetrapeptide arginine glycine aspartic acid serine. Receptor mediated endocytosis is a pivotal function of renal proximal tubule epithelial cells ptecs to reabsorb and metabolize substantial amounts of proteins and other substances in glomerular filtrates. Regulation of renal epithelial cell endocytosis of calcium oxalate monohydrate crystals american journal of physiology renal physiology.