Kidney Epidermal Growth Factor Receptor. Considerable support exists for the importance of the epidermal growth factor egf transforming growth factor alpha tgf α egf receptor egfr axis and of the adenylyl cyclase adenosine 3 5 cyclic monophosphate camp pathway in the. Furthermore increasing evidence indicates that epidermal growth factor receptor signaling is also involved in the development and progression of renal disease.
Low Levels Of Urinary Epidermal Growth Factor Predict Chronic Kidney Disease Progression In Children Sciencedirect from www.sciencedirect.com
However the therapeutic potential of egfr inhibition in these conditions is currently unknown. Advances in the understanding of cystogenesis identification of the pkhd1 gene and availability of a rat model the pck rat caused by a pkhd1 mutation facilitate testing of therapies for autosomal recessive polycystic kidney disease arpkd. Urinary epidermal growth factor uegf has recently been identified as a promising biomarker of chronic kidney disease ckd progression in adults with glomerular disease.
Egfr erbb 1 her2 neu erbb 2 her 3 erbb 3 and her 4 erbb 4.
However the therapeutic potential of egfr inhibition in these conditions is currently unknown. Epidermal growth factor receptor egfr is a receptor tyrosine kinase. The epidermal growth factor receptor egfr. However the therapeutic potential of egfr inhibition in these conditions is currently unknown.
