Kidney Disease And Liver Disease Increase The Risk Of Vitamin D Deficiency. In healthy subjects vitamin d s role in disease prevention runs the gamut of cancer to diabetes with only bone health firmly established. New york ny july 1 2013 vitamin d levels may be able to predict early kidney disease according to a new study published in the july issue of the national kidney foundation s american journal of kidney diseases.
Vitamin d deficiency is especially common in those with chronic kidney diseases due to the kidneys inability to convert vitamin d cholecalciferol into its active form calciferol. In the liver it undergoes a hydroxylation reaction to form 25 oh vitamin d 25d. Bone disease is a concern in chronic kidney disease but a deficiency in vitamin d can also affect heart health.
Vitamin d deficiency in ckd.
Researchers found that those who were deficient in vitamin d were more than twice as likely to develop albuminuria a type of protein in the urine over a period. Vitamin d is activated in the kidneys so those with kidney failure may need medicines to get their dose of vitamin d. Demonstrated that 25 hydroxyvitamin d values are 30 ng ml believed be the lower limit of normal in the majority of patients with ckd patients who are severely proteinuric have the lowest values. Many forms of 25 hydroylase have been described including cyp27a1 cyp2dii cyp2d25 cyp3a4 cyp2s25 cyp2j3 and cyp2r1.