Kidney Cytochrome P450 Enzymes. Introduction the cytochrome p450 dependent microsomal monooxygenase system is the most important group of enzymes. Cytochrome p 450 enzyme system.
The p450 enzymes contribute to metabolism of drugs by oxidation. Additionally p450 and drug transport protein expression were evaluated in cadaveric liver samples from esrd patients. Harris jw rahman a kim br guengerich fp collins jm.
Terminal activation of vitamin d3 to its hormonal form 1α 25 dihydroxyvitamin d3 1 25 oh 2d3 occurs in the kidney via the cytochrome p450 enzyme cyp27b1.
In this study the effect of protocatechuic acid on murine cytochrome p450 and phase ii enzymes was evaluated. This works to make the drug more water soluble as this form is the easiest for your kidney to filter. We used an adenine fed rat model of ckd to demonstrate that epo decreases expression and function of hepatic cyp3a2. Participation of cytochrome p450 3a4 and an unknown p450 enzyme.