Kidney Biopsy Multiple Myeloma. Tamm horsfall protein was identified within myeloma casts and the glomerular urinary space suggesting that tubular obstruction and retrograde urine flow precedes the development of myeloma kidney and acute renal failure. 1 mm represents 1 of all malignancies and almost 10 of haematologic malignancies.
The effect of multiple myeloma on the glomerulus filter due to light chain heavy chain deposition and amyloidosis will be reviewed on this web site under those specific topics. A renal biopsy in all four cases revealed the typical diagnostic features of myeloma kidney and led to confirmation of the diagnosis by bone marrow examination. Tamm horsfall protein was identified within myeloma casts and the glomerular urinary space suggesting that tubular obstruction and retrograde urine flow precedes the development of myeloma kidney and acute renal failure.
The effect of multiple myeloma on the glomerulus filter due to light chain heavy chain deposition and amyloidosis will be reviewed on this web site under those specific topics.
2 it is more common in elderly patients with a median age of diagnosis of 70 years males and african americans. 2 it is more common in elderly patients with a median age of diagnosis of 70 years males and african americans. Multiple myeloma mm is the result of a proliferation of a neoplastic clone of plasma cells in the bone marrow and encompasses 13 of all haematologic malignancies showing an annual incidence of 60 cases per million population clinical manifestations are heterogeneous ranging from skeletal disease 70 anaemia 40 impaired humoural immunity 80 and as we will. Multiple myeloma can affect the kidney in several ways.