Hypoxic Kidney Tubular Epithelial Cells. Of these hif α has two major active isoforms hif 1α and hif 2α. Hif 1α is primarily expressed in the tubular epithelial cells of the hypoxic kidney and functions as a master regulator of cellular adaptation to hypoxia 15 16.
This study aimed to probe the role of lon. 1 department of medicine case western reserve university school of medicine metrohealth medical center cleveland ohio 44109 usa. In conclusion our experimental data provide clear in vitro and in vivo evidence for the first time that bmi1 is involved in hypoxia induced emt in human renal tubular epithelial cells and renal fibrosis.
Hif 1α is primarily expressed in the tubular epithelial cells of the hypoxic kidney and functions as a master regulator of cellular adaptation to hypoxia 15 16.
1 department of medicine case western reserve university school of medicine metrohealth medical center cleveland ohio 44109 usa. Chronic hypoxia and tubulointerstitial injury are final common pathways in progression to end stage renal disease nangaku 2006. Meanwhile in renal tubular epithelial cells increased expression of key enzymes of glycolysis the level of glycolysis as well as lactate metabolites cooperatively led to hypoxic and acidic environment eventually inhibiting the proliferation and differentiation of podocytes and aggravating fibrosis. Hypoxia induces renal tubular epithelial cell apoptosis in chronic renal disease.