Epithelial Cells And Kidney Stones. Renal epithelial cells can synthesize a variety of cytokines chemoattractants and other molecules with the potential to interface with inflammatory cells. The effect of proteins isolated from human kidney stone was studied on com injured cells.
The presence of different inflammatory cells and molecules in the kidneys of rats with hyperoxaluria and in stone patients suggests that inflammatory responses play roles in stone disease. We have shown earlier that renal epithelial cells react to the presence of brushite and caox crystals in time and concentration dependent manner 3 4. Testing for epithelial cells can help determine if a person has an infection kidney disease or other medical condition.
Renal epithelial cells can synthesize a variety of cytokines chemoattractants and other molecules with the potential to interface with inflammatory cells.
The effect of proteins isolated from human kidney stone was studied on com injured cells. The development of struvite stones is favored by the bacterial enzyme urease that splits the bacteria into ammonia and carbon dioxide thereby making the urine. The renal epithelial cells mdck were exposed to 200 μg ml com crystals to induce injury. Renal epithelial cells can synthesize a variety of cytokines chemoattractants and other molecules with the potential to interface with inflammatory cells.