Cisplatin Kidney Epithelial Cells. However during this process cisplatin accumulates in the kidney tubular epithelial cells and injuries the cells through various pathways. Tests of kidney function and tubular injury in renal tissues and urine together with oxidative stress and inflammation markers were examined.
Cisplatin is mainly removed from the body through excretion via the kidneys. In the present study we found that pyroptosis was induced by cisplatin in both mouse kidney tissues and renal tubular epithelial cells accompanied by increased expression of the gsdmd n fragment. Cisplatin induced shortening elongation and normalization of the primary cilia in kidney epithelial cells over time.
In contrast the reduced function mutations of oct2 leading to lower exposure of cisplatin in the kidney are associated with reduced cisplatin related nephrotoxicity in cancer patients.
Among which oxidative stress is a major factor. However during this process cisplatin accumulates in the kidney tubular epithelial cells and injuries the cells through various pathways. Tangeretin ameliorated cisplatin induced elevations in serum creatinine bun and histopathologic changes. In gsdmd knockout mice with cisplatin induced aki we found that cisplatin induced loss of renal function renal tubular injury and inflammation was significantly attenuated compared with wild type mice.